Spravato is a nasal spray medication that is used for the treatment of depression, specifically for adults with treatment-resistant depression (TRD). It is a relatively new medication that was approved by the U.S. Food and Drug Administration (FDA) in 2019. The administration process and frequency of Spravato can vary depending on several factors, such as the patient’s condition, response to treatment, and the healthcare provider’s recommendations.
Understanding Spravato: An Overview
What is Spravato?
Spravato is the brand name for esketamine, which is a derivative of ketamine. It is a nasal spray that is used in conjunction with an oral antidepressant medication to treat TRD. Unlike traditional antidepressants, Spravato works by targeting the glutamate system in the brain, which plays a role in mood regulation.
Patients undergoing Spravato treatment are closely monitored due to the nature of the medication and its potential side effects. The administration of Spravato is done in a healthcare setting under the supervision of a healthcare provider to ensure safety and efficacy. The innovative delivery method of a nasal spray has made it more convenient for patients compared to traditional intravenous ketamine infusions.
The Medical Use of Spravato
Spravato is specifically indicated for adults with TRD who have not responded adequately to at least two other antidepressant treatments. This makes it an important treatment option for individuals who have struggled to find relief from their depression symptoms.
The approval of Spravato by regulatory bodies signifies a shift in the treatment landscape for depression, paving the way for more research and development in novel therapeutics. The introduction of Spravato has sparked discussions among healthcare professionals about the future of mental health care and the potential for personalized medicine in treating psychiatric disorders.
The Administration Process of Spravato
Preparing for Spravato Administration
Prior to each Spravato administration, the patient is instructed to avoid eating or drinking for at least two hours. They are also advised to empty their bladder before the administration begins. These instructions are key to ensure the safe and effective administration of the medication.
Patients are usually required to undergo a brief assessment to evaluate their current mental and physical state. This assessment helps healthcare providers determine the patient’s readiness for the treatment and identify any potential risk factors that may require special attention during the administration process.
The Role of Healthcare Providers in Spravato Administration
Healthcare providers play a crucial role in the administration of Spravato. They are responsible for preparing and administering the medication, as well as monitoring the patient during and after the administration. This close monitoring is important to detect and manage any potential side effects or adverse reactions. Healthcare providers are trained to recognize the signs of dissociation, a common side effect of Spravato treatment.
Dissociation is a temporary state where a person may feel disconnected from their thoughts, feelings, and surroundings. By closely monitoring the patient’s vital signs and behavior, healthcare providers can intervene promptly if dissociation occurs, ensuring the patient’s safety and well-being throughout the treatment session.
Frequency of Spravato Administration
Initial Phase of Spravato Administration
During the initial phase of Spravato treatment, the medication is typically administered two times per week for the first four weeks. This frequent administration helps to establish the initial antidepressant effect and optimize the patient’s response to treatment.
It is important for patients undergoing the initial phase of Spravato administration to closely follow the prescribed schedule to maximize the benefits of the treatment. Regular communication with healthcare providers can help address any concerns or adjustments that may be needed during this critical phase.
Maintenance Phase of Spravato Administration
After the initial phase, the frequency of Spravato administration may be adjusted based on the patient’s response to treatment. In general, the maintenance phase involves weekly or bi-weekly administration of the medication. However, healthcare providers may tailor the frequency based on the individual needs of the patient.
During the maintenance phase, patients are encouraged to maintain open communication with their healthcare providers to discuss any changes in their condition or response to the medication. This collaborative approach ensures that the treatment plan remains effective and tailored to the specific needs of each individual.
Factors Influencing Spravato Administration Frequency
Patient’s Health Condition
The patient’s overall health condition can impact the frequency of Spravato administration. Factors such as the severity of depression symptoms, any comorbid medical conditions, and the patient’s overall treatment response are taken into consideration when determining the appropriate administration frequency.
Mental health history and past treatment experiences are also crucial in determining the optimal frequency of Spravato administration. Patients with a history of treatment-resistant depression may require a more frequent administration schedule to achieve desired therapeutic outcomes, while those with a milder form of depression may benefit from a less frequent schedule.
Response to Treatment
The patient’s response to Spravato treatment is closely monitored throughout the course of treatment. If the patient demonstrates significant improvement in their depression symptoms, the healthcare provider may consider reducing the frequency of administration. Conversely, if the patient does not show adequate improvement, the frequency may be increased or alternative treatment options may be explored.
Additionally, the presence of any side effects or adverse reactions to Spravato can also influence the administration frequency. Patients experiencing severe side effects may require a lower frequency of administration to minimize discomfort and ensure safety. On the other hand, patients who tolerate the treatment well may be candidates for a more frequent administration schedule to optimize therapeutic benefits.
Potential Side Effects and Risks of Spravato
Serious Risks and Precautions
While the common side effects of Spravato are generally mild and transient, it’s important to be aware of the serious risks and precautions associated with this medication. One significant concern is the potential for abuse and misuse. Spravato contains esketamine, which is a
Schedule III controlled substance due to its potential for abuse. Therefore, healthcare providers carefully assess each patient’s suitability for Spravato treatment and closely monitor them throughout the course of administration to ensure that the medication is used appropriately and safely.
Another serious risk to consider is the potential for sedation and dissociation. These effects can impair your cognitive and motor skills, making it unsafe to drive or operate heavy machinery. It is crucial to follow your healthcare provider’s instructions regarding activities to avoid while taking Spravato and to have a responsible adult accompany you during and after each treatment session to ensure your safety.
It is worth emphasizing that the safe and effective use of Spravato relies heavily on the involvement of healthcare providers. They play a crucial role in monitoring your progress, managing any potential side effects or risks, and adjusting the frequency of administration based on your individual response to treatment.
The frequency of Spravato administration may vary from the initial phase to the maintenance phase, depending on factors such as your health condition and treatment response. Therefore, it is essential to maintain open communication with your healthcare provider and work closely together to determine the appropriate frequency of Spravato administration that best suits your specific needs.
To learn if Spravato is the right treatment for you, reach out to us at West Coast Ketamine Center today to schedule a mental health consultation.
